The group of 50 will travel over 60km after they leave Campbelltown Stadium at 5.30am Friday morning, stopping over at the Eels' Parramatta Stadium, before making it to Leichhardt Oval to see Wests Tigers host Parramatta Eels.
Wests Tigers will donate money from the auction of one of the strictly limited "Skyfall" jerseys which the club will wear on Friday night.
The Club's charity partner, Children's Cancer Institute Australia has partnered with Parramatta's partner Westmead Children's Hospital to throw their support behind the effort.
Organiser Carol Wilson has coordinated the walk after losing husband Bob to cancer.
She is encouraging anyone who can spare any amount possible to donate HERE.
The group will receive a presentation from Wests Tigers on Leichhardt Oval during match night.