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Just two weeks on from their biggest defeat of the season, Wests Tigers will field essentially a brand new spine for Sunday's must-win clash against the Gold Coast.

Only Luke Brooks remains in position from the Round 15 loss to Canberra, with Moses Mbye (fullback), Josh Reynolds (five-eighth) and Robbie Farah (hooker) all slotting in for Sunday's game at Leichhardt.

Incredibly, it'll be the 10th different spine combination used by Ivan Cleary this season, and Reynolds knows there's a high expectation on the attacking quartet to fire from the word go this weekend.

"As a spine, we really have to be confident with each other and the game plan," he said.

"We have to really know what we're doing so the boys know what we're doing as a team.

"We don't want to get towards the back end of the season and need to win three from three, so it's really important we get that combination and play some good footy that we can take in to the final few rounds.

"With that extra knowledge from the new guys that have come in, it's a different thing for us and it's going to be good. But it just doesn't come and combinations don't just develop because you're a good player.

"You've really got to work at it and make sure you're ready to buy in whatever you're doing."

While it might be the 10th different spine combination used for Wests Tigers, it will also be the most experienced one taking the field for the home side this weekend, with the 29-year-old Reynolds highlighting the importance of having that additional leadership out there this weekend.

"It definitely feels different with those boys here because it's a totally new spine," Reynolds said.

"But it's good for the club in general, especially having Robbie back here. He's done a lot for this club and put his body on the line for many years so it's great to have him be so well-received.

"And for Moses too, being back playing with him again is special for me.

"He seems really excited — they say that change is as good as a holiday and you can really see that in him.

"I can't wait to run out there with him, and I'm pretty pumped to be able to share that moment with them."

"To put someone like Robbie Farah in a team really adds something extra," he said.

"He might not have been playing a lot of first-grade this year but I definitely remember how good a player he is. He knows the game really well and that'll definitely help me and it'll help Brooksy too.

"We've got to organise ourselves and what we're going to do, so it's good to have someone who can help organise the forwards and the ruck and also take the right options at time with his crafty left foot.

"You can definitely feel a bit of a buzz around the place."

While much of the focus on Wests Tigers this week has been the arrivals of both Mbye and Farah, it's clear that the focus has still remained on getting the job done on Sunday against the Gold Coast Titans.

Three defeats in a row have seen Cleary's side drop four points behind the top eight, and with the bye coming up in Round 17, Sunday's game is shaping as a traditional "four-pointer" at Leichhardt Oval.

"At the end of the day, whether those guys came or didn't, we really need to dig deep," Reynolds enthused.

"We're on the wrong side of the top eight now and it's definitely a big game this Sunday ahead of the bye.

"It's a hard game for us. The Titans came out and smoked the Bulldogs at Belmore so they're not going to care that it's at Leichhardt — they just want to come and spoil the party once more for us."

See what Josh Reynolds had to say in full about this week's game in the video above!