Wests Tigers have won two of their four games so far in 2013, while Melbourne are three wins from four starts.
Coach Todd Payten's reigning Premiers have continued their brand of tough, committed football in 2013, conceding the least points of any team (76).
Melbourne hold fourth place on the Holden Cup ladder and Wests Tigers can over-take them with a win of 13 points or more.
Wests Tigers coach sees the strong Melbourne side as a serious threat.
"They play similar in structure to the first grade side," said Payten.
"Cade Umaga in the back row is devastating on the edge. He possesses a good offload pre and in the line.
"Hooker Alex Langbridge is crafty out of dummy half taking advantage of their big forwards hard work and Denny Solomona at the back is strong and elusive.
"Again our professionalism will be tested with the travel down on the day. I have said it before it should not be a problem if we are prepared and professional about the day."