After representing City in Coffs Harbour over the weekend, Tedesco will move to his preferred position of fullback after playing on the wing over the past few weeks.
Moltzen will move from fullback replace the injured Braith Anasta at halfback, with the side looking to bounce back from a disappointing 13-12 loss to the Dragons a fortnight ago.
James Tedesco has had an enormous build up for this, Potter said.
I've been really impressed with the way he's come through. He's had a couple of State Cup games and he's got better and better and now a couple of NRL games.
I'm happy with how he's gone and he deserves his start at fullback.
With a horrid run of injuries, including those of key playmakers Benji Marshall and Braith Anasta, Potter is confident he has chosen the right combination for this weekend.
Tim Moltzen has done a lot of training in the pre-season in the halves, Potter said.
Curtis Sironen has had a very, very steep build up into this match.
He got selected in the City team and did alright for them,
He'll be better for the run out and I'm looking forward to seeing him in the number six jersey.
Three matches will be played at Campbelltown Sports Stadium in what is sure to be a great evening of Rugby League.
Gates will open at 3:15pm for kick-off of the Ron Massey Cup, followed by Under 20s and then NRL, which will get underway at 7:30pm.
The full team will be released later this afternoon, keep an eye on weststigers.com.au for the announcement.
BUY TICKETS TO WESTS TIGERS VS BRONCOS
BANNER MAKING COMPETITION WITH BENJI, LOTE AND KEITH