Victory at ANZ Stadium will see the sixth placed Wests Tigers have the opportunity to push for a top four position subject to weekend results. Wests Tigers have won three of their past four matches.
The Rabbitohs may be sitting in 13th position on the ladder but Wests Tigers Coach Todd Payten says the opposition is a team beaming with talent.
"Their forward pack is underrated and hard working and have lightning speed out wide,'' Payten said.
"Centre Aaron Gray has been playing in the NSW Cup for the last few weeks. They are also well coached by Grant Jones."
Kick-off is 5.20pm.