Wests Tigers began the game with plenty of aggression, but it was South Sydney who got off to a flying start.
Winger Nathan Merritt opened the scoring in the right corner taking a pass from giant fullback Greg Inglis to squeeze between a desperate Koroibete and the sideline.
Adam Reynolds missed the goal leaving the score 4-0 to the Rabbitohs after 4 minutes.
Souths were at it again not long afterwards and debutant Dylan Walker score under the posts backing up a break by Bryson Goodwin.
Reynolds converted for a 10-0 lead after 11 minutes.
Rabbitohs fullback Greg Inglis stretched even further and Reynolds converted to make it 16-0 after 13 minutes.
Benji Marshall came off the bench and gave a short ball to Eddy Pettybourne, but the former Rabbitoh was unable to ground the ball.
The flood gates were well and truly open when South Sydney centre Beau Champion glided wide on the right following a misread in defence.
Reynolds converted again to see Souths going at a point-a-minute 22-0.
Giant English forward George Burgess continued to push his world cup claims barging over after sustained Rabbitohs pressure.
South Sydney were rampant as Reynolds added the extras to lead 28-0.
Sam Burgess wasn't to be outdone by his younger brother, crashing over himself with Reynolds' conversion giving Souths an unbelievable 34-0 lead after just 28 minutes.
Wests Tigers captain Robbie Farah continued to fight, diving over from dummy half to claim a try. The video ref wasn't impressed though and ruled the NSW star held up.
It was inevitable that man of the moment Greg Inglis would go the length of the field at some point and he did just that in the 35th minute. Five Wests Tigers players showed great heart giving chase but couldn't reel the Kangaroo star in.
Wests Tigers scored arguably the try of the game late in the second half, Marshall and Farah combining to produce an exciting try for Koroibete right on half time.
Sironen missed the conversion leaving the score at 38-4 at the break.
Wests Tigers started the half brightly but Curtis Sironen was denied a try for obstruction.
Wests Tigers made a break through front rower Aaron Woods, but the big man turned the ball over when attempting to set up his support runners.
South Sydney immediately made Wests Tigers pay, halfback Adam Reynolds seizing on the unset defence to streak away. He converted his own try to give the Rabbitohs a 44-4 lead.
Inglis had his hat trick in the 61st minute backing up to cruise under the posts. Adam Reynolds' conversion brought up 50 points for South Sydney.
The rate of scoring slowed right down in the second half. Debutant Wests Tigers winger David Nofoaluma sparked an exciting passage of play for his team with a 40 metre break.
Farah and Marshall combined to send Simona soccering the ball down the touchline but even some acrobatics couldn't produce a try for Wests Tigers.
Liam Fulton grabbed a late try for Wests Tigers stretching over to plant the ball. Sironen's conversion made the score 50-10.
Greg Inglis produced the amazing once more to ground the ball from a grubber, finishing with four tries for the night.
Final score 54-10 South Sydney defeating Wests Tigers.