Newcastle opened the scoring in 7th minute when halfback Adrian Davis showed good speed to dummy and go from close range on the left.
Wests Tigers Coach Paul Fletcher would have been unhappy with the defensive effort, his troops conceding points at Newcastle's first attempt on their line.
Joshn Mantellato converted from the sideline to give the Knights a 6-0 lead.
Wests Tigers were making too many errors and when Meaney failed to find touch, Newcastle capitalised again.
Second Rower Zane Tetevano punched straight through the heart of the Wests Tigers defence from 30 metres out, never pausing to deviate as he ran straight over the top of fullback Meaney to touch down under the posts.
Mantellato converted easily to send the score to 12-0 in the 15th minute.
Moses Pangai came up with a great effort to take a quick tap restart and send Jack Madden into the clear, but the halfback simply dropped the pass.
Newcastle punished Wests Tigers in the 21st minute, second rower Korbin Sims too big and too powerful for the defence from close range.
Mantellato missed his first for the afternoon leaving the score at 16-0.
Captain Sean Meaney was forced to limp from the field with an ankle injury.
Wests Tigers had their chances and looked to be able to expose the Newcastle defence, but simple errors were ruining any chance of getting on the score board, Rory Brien putting the ball down with the line open.
Newcastle were on the board again in the 29th minute, winger Chanel Mata'utia scoring on the left after James Gavet had given away an unnecessary penalty on the last tackle.
Mantellato made no mistake, and the score was looking ugly for Wests Tigers, Newcastle up 22-0.
It was getting embarrassing for Wests Tigers when giant forward Dylan Smith powered through the middle of the defence 30 metres out before dummying and going himself to score in the 34th minute.
Mantellato converted and the score was 28-0 just before the halftime break.
More unforced errors before halftime summed up the afternoon so far for Paul Fletcher's men and the Coach would surely have been glad to get the team into the sheds.
Captain Sean Meaney returned from an ankle injury to lead the Wests Tigers out for the second half.
It looked like a different Wests Tigers side in the second half and Josh Davis powered over out on the left hand side after just two minutes of play, but the centre dropped the ball over the line.
Wests Tigers would have more chances in the opening five minutes of the second half, but poor ball handling was still costing them.
There was plenty of spice in the game, with a number of disagreements between the two sides. Newcastle halfback Adrian Davis was sin binned in the 48th minute after starting a fight with opposite number Jack Madden.
Wests Tigers had had the bulk of possession and field position, but couldn't manage to finish a set, let alone post their first points.
Wests Tigers winger Moses Pangai joined Davis in the sin bin in the 50th minute, after giving away a penalty in the wrestle.
Wests Tigers finally worked the scoreboard in the 58th minute when right winger Sitaleki Akauola finished well in the corner.
Sean Meaney couldn't convert from the sideline, leaving the score at 28-4.
Newcastle looked to have snuffed out any chance of a comeback when five-eighth Tyler Randall evaded the kick pressure on the last tackle, electing to run the ball, and going all the way.
Mantellato missed from the sideline, the score staying at 32-4 in the 63rd minute.
Wests Tigers hadn't thrown the towel in, David Harris scoring a try under the posts after Farlow banana kicked back under the posts in the 69th minute.
Meaney converted and the Wests Tigers trailed by 22 points with nine minutes remaining.
Newcastle put the icing on their cake with two minutes remaining when front rower Joseph Tapine charged over next to the posts.
Mantellato converted to push the scoreline to 38-10.
That would be the final score and the final time Wests Tigers would feature in 2013 as they crashed out of the NSW Cup.
It was a case of what if for the Wests Tigers who had shown themselves more than capable of matching the Knights, but the error rate was simply too high to win a semi final.
Newcastle ran out winners over Wests Tigers 38-10.